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  • Title: Activin as a morphogen in Xenopus mesoderm induction.
    Author: McDowell N, Gurdon JB.
    Journal: Semin Cell Dev Biol; 1999 Jun; 10(3):311-7. PubMed ID: 10441545.
    Abstract:
    Activin, a member of the Transforming Growth Factor beta (TGF-beta) superfamily, can behave as a morphogen in cells of the early Xenopus embryo by inducing a range of mesodermal genes in a concentration-dependent manner. This review examines the behaviour of activin as it forms a morphogen gradient. It also discusses how a cell can perceive its position in a concentration gradient in order to activate appropriate mesodermal gene responses.
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