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  • Title: Occult sporadic medullary microcarcinoma with lymph node metastases.
    Author: Sironi M, Cozzi L, Pareschi R, Spreafico GL, Assi A.
    Journal: Diagn Cytopathol; 1999 Sep; 21(3):203-6. PubMed ID: 10450108.
    Abstract:
    A sporadic form of medullary occult microcarcinoma was cytologically diagnosed, by fine-needle aspiration biopsy (FNAB), on metastatic cervical lymph nodes. The cytologic specimens were partially smeared and partially zinc-formalin-fixed, so that a microinclusion clot for immunohistochemical studies would be possible. The reactivity to calcitonin of neoplastic cells obtained from metastatic cervical lymph nodes supported the search for a thyroid tumor, which only a careful echographic study revealed. Under sonographic guidance, FNAB on a 0.5-cm hypoechoid nodule was performed. The smears were diagnostic of medullary carcinoma. A total thyroidectomy with node dissection was made. Diagn. Cytopathol. 1999;21:203-206.
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