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Title: Lack of topographical specificity in peripheral nerve regeneration in rats. Author: Iwabuchi Y, Maki Y, Yoshizu T, Narisawa H. Journal: Scand J Plast Reconstr Surg Hand Surg; 1999 Jun; 33(2):181-5. PubMed ID: 10450575. Abstract: In a previous study we found that sensory regeneration was neurotropically selective regardless of the end organ, but motor regeneration was not, which made us doubt the existence of topographic specificity. The purpose of the present study was to confirm the existence of topographic specificity in rats. The proximal stump of either the peroneal or tibial nerve was inserted into the proximal limb of a silicone Y-chamber. Both distal stumps of peroneal and tibial nerve were inserted into the distal limbs. The gap between the stumps was set at either 4 mm (n = 8, on each subgroup) or 8 mm (n = 8, on each subgroup). Six weeks later the number of regenerated axons in the distal two limbs were counted and compared. The number of regenerated axons towards the distal tibial nerve side was significantly larger in every model. Regenerated axons from the proximal peroneal stump did not preferentially choose the distal peroneal stump. The existence of topographic specificity is unlikely.[Abstract] [Full Text] [Related] [New Search]