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  • Title: [Transcription factors of the Ets family and morphogenesis of the vascular tree].
    Author: Mattot V, Vercamer C, Soncin F, Fafeur V, Vandenbunder B.
    Journal: J Soc Biol; 1999; 193(2):147-53. PubMed ID: 10451348.
    Abstract:
    The expression of several members of the Ets family of transcription factors, Ets1, Erg and Fli, correlates with the occurrence of invasive processes such as angiogenesis during normal and pathological development. The description of the phenotype of cultured endothelial cells expressing the DNA binding domain of Ets1 suggests that members of the Ets family take part in the morphogenesis of the vascular tree. Although transient transfection experiments allowed the identification of putative targets genes for Ets1 during angiogenesis, deciphering the Ets1 regulation networks remains a major goal for the future.
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