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  • Title: [A study of immunopathology on salivary gland of Sjögren's syndrome].
    Author: Luo F, Zhang H, Zhou Z.
    Journal: Zhonghua Yan Ke Za Zhi; 1997 Sep; 33(5):363-5. PubMed ID: 10451983.
    Abstract:
    OBJECTIVE: To understand the mechanism and pathogenesis of Sjögrens syndrome (SS) and to provide theoretical basis for the treatment of SS. METHOD: Salivary gland lymphocytes (SGL) from 20 patients with SS were analyzed by using immunohistochemical avidin-biotin-peroxidase complex (ABC) method. RESULT: A predominance of T cells was found in SGL with the majority belonging to the CD4+(TH), and the CD8+(TS) subset was obviously decreased, while the CD4+/CD8+ ratio was considerably increased. Most lymphocytes expressed HLA-DR antigen in SS. The deficiency of Ts and the overactivity of TH would result in autoantibody production, that would contribute to the reaction of autoimmune. CONCLUSION: The immune hyperfunction at exocrine glands of SS is the direct cause of the pathogenesis of SS. SS is further proved to be an autoimmune disease.
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