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  • Title: Blood leukocyte and glutamine fluctuations after eccentric exercise.
    Author: Miles MP, Naukam RJ, Hackney AC, Clarkson PM.
    Journal: Int J Sports Med; 1999 Jul; 20(5):322-7. PubMed ID: 10452230.
    Abstract:
    Skeletal muscle, as a producer of glutamine, is important for lymphocytes, monocytes and macrophages. Exercise-induced muscle damage could burden the immune system by concurrently eliciting a local inflammatory response and decreasing glutamine availability. The aim of this study was to determine whether blood leukocyte and glutamine concentrations were affected in individuals with high serum creatine kinase (CK) activity (indirect indication of muscle damage) compared to those with no change in CK. Twelve females performed maximal eccentric resistance exercise using one arm and one leg. Blood leukocyte subsets and glutamine were measured at 24 and 0 h pre-exercise, and post-exercise at intervals up to 9 d post-exercise. Eleven subjects were placed in High (n = 6) and Low CK (n = 5) groups. Lymphocytes, (total, natural killer, and T), monocytes, and granulocytes did not change significantly in either group, at any time. Whole blood glutamine concentration decreased (p < 0.05) from 437 microM pre-exercise to 332 microM 3 d post-exercise in both groups. The decrease in glutamine suggests that the metabolism of the muscle may be affected by this exercise, however, the occurrence of this decrease in both groups suggests that this change was not a response to muscle damage.
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