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  • Title: [Cloning of genes associated with taxol-induced apoptosis of human breast cancer cells].
    Author: Chen L, Zheng S, Willingham MC, Fan W.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1997 Jun; 19(3):197-203. PubMed ID: 10453491.
    Abstract:
    The method of mRNA differential display was employed to isolate expressing genes involved in taxol-induced apoptosis of human breast cancer cells (BCap 37). Results demonstrated that the expressive alteration of twelve clones isolated was associated with taxol-induced apoptosis identified by Northern blot. cDNA sequence of clone C3P3 was highly homologous (99%) to human S-adenosylmethionine (S-AdoMet) synthetase. Increased transcriptional level of clone C3P3 induced by taxol was parallel to enhanced enzyme activity of S-AdoMet synthetase. These results suggested that the expression of these clones isolated by the mRNA differential display be possibly involved in the regulation of taxol-induced apoptosis. Their function in details need further study.
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