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  • Title: [Study on the effect of ofloxacin and tanshinone II A on human leukocyte chemotactic migration in vitro].
    Author: Zhou Z, Zheng J, Xu W.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1997 Jun; 19(3):232-5. PubMed ID: 10453497.
    Abstract:
    In order to verify the possible anti-inflammatory activity and their potency of ofloxacin and Tanshinone II a, the effects of different concentrations of ofloxacin, Tanshinone II a and hydrocortisone on human leukocyte migration in vitro were investigated employing agarose migration technique in which f-Met-Lea-Phe was served as chemotactic factor. The results showed that all the three agents could inhibit migration of leukocytes remarkably. The effects were concentration-dependent with excellent linear relationship. The IC50 were: Tanshinone II a 0.46 microgram/ml, ofloxacin 0.63 microgram/ml, and hydrocortisone 46.52 micrograms/ml respectively. The results indicated that Tanshinone II a was the most potent agent for inhibiting migration of human leukocytes in vitro and the hydrocortisone was relatively less potent.
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