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  • Title: [Study of mechanism of PTH modulating cytosolic free calcium in rat DCT].
    Author: Song Y, Cheng J, Duan J, Liu J.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1997 Dec; 19(6):419-23. PubMed ID: 10453532.
    Abstract:
    OBJECTIVE AND METHODS: In order to understand the mechanism of PTH in regulating cytosolic free calcium concentration ([Ca2+]i), we differentiated rat renal proximal and distal convoluted tubules (PCT&DCT) by Percoll density gradient centrifugation, and successfully gauged the effect of hPTH (1-84), dibutyryl cAMP (db cAMP, a kind of cAMP activator) and prostaglandin E2 (PGE2) on [Ca2+]i of DCT using fluorescent Ca2+ indicator Fluo 3-AM. We found that PTH, db cAMP and PGE2 all could increase [Ca2+]i. RESULTS: The results suggest that the rise in [Ca2+]i induced by PTH in DCT was through activation of cAMP, and PGE2 might be also involved in regulation of [Ca2+]i as a messenger of PTH.
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