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  • Title: Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH.
    Author: Armelin HA, Lotfi CF.
    Journal: Braz J Med Biol Res; 1999 Jul; 32(7):841-3. PubMed ID: 10454742.
    Abstract:
    FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.
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