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  • Title: Blastocyst implantation: effect of thyroidectomy and thyroxine replacement in the rat.
    Author: Bolarinwa AF, Olaleye SB.
    Journal: Afr J Med Med Sci; 1997; 26(3-4):135-7. PubMed ID: 10456155.
    Abstract:
    The long term effects of thyroidectomy and chronic thyroxine treatment on blastocyst implantations in female albino rats were studies. Implantation was delayed in both thyroidectomized and hyperthyroid rats, as there was no evidence of blastocyst implantation on day 6 of pregnancy. By day 9, when signs of implantation were observed, the number and weights of the implantation sites were significantly reduced in the athyroid and hyperthyroid rats. Both thyroidectomy and chronic thyroxine treatment significantly reduced the fetal sites and increased the incidence of resorptions when compared with the control. It is concluded that a functional thyroid gland is required for normal implantation to occur.
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