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  • Title: Influence of theophylline on urinary excretion of total, free and acyl carnitine in rats.
    Author: al-Kholaifi AM, Alhomida AS.
    Journal: In Vivo; 1999; 13(3):225-9. PubMed ID: 10459496.
    Abstract:
    BACKGROUND: Carnitine plays a critical role in lipid metabolism. Carnitine deficiency may adversely affect the oxidation of fatty acids and further aggravate abnormal lipid metabolism. OBJECTIVE: To investigate the effect of oral theophylline administration on urinary excretion of total (TC), free (FC), acyl (AC) carnitine as well as the ratio of AC to FC in rats. METHOD: The study was a randomized, controlled animal study. Theophylline was given at 100 mg/kg b.w./day and effects were monitored after a treatment period that lasted between one week and five weeks. RESULTS: Theophylline treatment caused significantly increased food intake and urinary excretion as compared to either control or placebo, P < 0.01. The results indicated that a significant increase in urinary TC, FC and AC excretion as compared to those of control and placebo groups (P < 0.01). Furthermore, the ratio of AC to FC was significantly increased (P < 0.01) as compared to either control or placebo group. CONCLUSION: Theophylline administration to rats leads to significant changes in the urinary excretion of carnitine. These changes may result from theophylline-affected alteration renal tubular re-absorption of carnitine.
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