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  • Title: Unequal pronuclear size--a powerful predictor of embryonic chromosome anomalies.
    Author: Manor D, Drugan A, Stein D, Pillar M, Itskovitz-Eldor J.
    Journal: J Assist Reprod Genet; 1999 Aug; 16(7):385-9. PubMed ID: 10459523.
    Abstract:
    PURPOSE: Our purpose was to evaluate whether pronuclei of unequal size, observed in 13.7% of zygotes evaluated after in vitro fertilization (IVF), are predictive of chromosome anomalies in the developing embryo. METHODS: Five ploidy of 38 embryos grown from zygotes with unequal-sized pronuclei was assessed by fluorescent in situ hybridization (FISH). Twenty-six embryos developed after intracytoplasmic injection of sperm (ICSI) and 12 embryos were derived from conventional IVF. RESULTS: Chromosome anomalies were documented in the ICSI and IVF groups in 88.5 and 50% of cases, respectively. CONCLUSIONS: We suggest that FISH should be employed to examine the ploidy of zygotes with unequal pronuclei, prior to embryo transfer.
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