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  • Title: Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent.
    Author: Mashiko H, Niwa S, Kumashiro H, Kaneko Y, Suzuki S, Numata Y, Horikoshi R, Watanabe Y.
    Journal: Psychiatry Clin Neurosci; 1999 Apr; 53(2):193-4. PubMed ID: 10459686.
    Abstract:
    This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.
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