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  • Title: Calcium channel activation stabilizes a neuronal calcium channel mRNA.
    Author: Schorge S, Gupta S, Lin Z, McEnery MW, Lipscombe D.
    Journal: Nat Neurosci; 1999 Sep; 2(9):785-90. PubMed ID: 10461216.
    Abstract:
    We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged. This stabilizing effect of depolarization is mediated through the 3' untranslated region of a long form of the alpha1B mRNA and may represent a form of modulation of N-channel levels that does not require changes in gene transcription. Increases in N channel expression would affect several key neuronal functions controlled by calcium, including transmitter release and neurite outgrowth.
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