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  • Title: Mid-dermal elastolysis associated with Hashimoto's thyroiditis.
    Author: Gambichler T, Linhart C, Wolter M.
    Journal: J Eur Acad Dermatol Venereol; 1999 May; 12(3):245-9. PubMed ID: 10461647.
    Abstract:
    We report the case of a 38-year-old Caucasian female presenting asymptomatic plaques of fine wrinkling and perifollicular papular protrusions especially on the trunk. Histological examination evidenced loss of elastic fibers in the mid-dermis due to elastophagocytosis, with giant cells and granuloma formation. Moreover, elevated titers of thyroid autoantibodies were detected and thyroid ultrasound revealed echo-poor tissue. These findings met the diagnoses of mid-dermal elastolysis and Hashimoto's thyroiditis. This association has not been reported before. We present a comprehensive overview of the literature and discuss the pathogenetic aspects of mid-dermal elastolysis and the significance of the association with Hashimoto's thyroiditis.
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