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  • Title: Cystic fibrosis with fibrosing colonopathy in the absence of pancreatic enzymes.
    Author: Waters BL.
    Journal: Pediatr Dev Pathol; 1998; 1(1):74-8. PubMed ID: 10463274.
    Abstract:
    Fibrosing colonopathy, characterized by dense submucosal fibrosis in the large bowel, is a disorder associated with bowel dysfunction in patients with cystic fibrosis who receive pancreatic enzyme supplementation. Most commonly, patients present with a distended abdomen and abdominal pain. Radiographs frequently demonstrate colonic wall thickening and luminal narrowing. Here I describe a neonate with cystic fibrosis who presented with both clinical and histological features of fibrosing colonopathy who had not received pancreatic enzymes. This report expands our understanding of the pathogenesis of fibrosing colonopathy.
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