These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Splenectomy during partial remission in thrombotic thrombocytopenic purpura with prolonged plasma exchange dependency.
    Author: Mant MJ, Turner AR, Bruce D, Ritchie C, Larratt LM.
    Journal: Am J Hematol; 1999 Sep; 62(1):56-7. PubMed ID: 10467278.
    Abstract:
    Some patients with thrombotic thrombocytopenic purpura (TTP) remain plasma-exchange-dependent for prolonged periods of time. This exposes patients to risk, uses substantial resources, and requires prolonged hospitalization. We have splenectomized 7 such patients following 25-42 plasma exchanges while patients were in partial remission only and were clinically stable. In 6 patients, including 1 with TTP secondary to mitomycin C, thrombocytopenia promptly resolved. Relapse has not occurred during 18 or more months of observation. The seventh patient did not respond. We conclude that splenectomy should be considered as an alternative to continued plasma-exchange therapy in such patients.
    [Abstract] [Full Text] [Related] [New Search]