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  • Title: Successful related umbilical cord blood transplantation for graft failure following T cell-depleted non-identical bone marrow transplantation in a child with major histocompatibility complex class II deficiency.
    Author: Bonduel M, Pozo A, Zelazko M, Raslawski E, Delfino S, Rossi J, Figueroa C, Sackmann Muriel F.
    Journal: Bone Marrow Transplant; 1999 Aug; 24(4):437-40. PubMed ID: 10467337.
    Abstract:
    Major histocompatibility complex (MHC) class II deficiency is a rare form of primary combined immunodeficiency that can only be corrected by stem cell transplantation. We report a 4(1/2)-year-old girl with MHC class II deficiency who underwent a related CBT due to graft failure following T cell-depleted non-identical BMT. The patient is alive and well 2 years after the second transplant. A sustained hematopoietic engraftment and a progressive immune recovery have been detected. We conclude that cord blood may be an effective source of hematopoietic stem cells for patients with immuno- deficiency disorders including diseases with a high rate of graft failure.
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