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  • Title: Preparation and properties of glutaraldehyde cross-linked whey protein-based microcapsules containing theophylline.
    Author: Lee SJ, Rosenberg M.
    Journal: J Control Release; 1999 Aug 27; 61(1-2):123-36. PubMed ID: 10469909.
    Abstract:
    Whey protein-based microcapsules containing a model drug, theophylline, were prepared in organic phase, using glutaraldehyde-saturated toluene. In all cases, spherical microcapsules, ranging from <400 to 1000 microm in diameter, were obtained. Results indicated that core crystals were embedded throughout the wall matrix. In all cases, retention efficiency of theophylline was higher than 74% and was not affected by cross-linking conditions. Results of theophylline release in simulated intestinal and gastric fluids at 37 degrees C indicated that the diffusion-governed core release was significantly affected by size of microcapsules, cross-linking conditions, and by type of dissolution medium. In all cases, core release in simulated intestinal fluid was faster than in simulated gastric fluid.
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