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  • Title: Synthesis and antiproliferative activity of 2-triazenothiophenes.
    Author: Diana P, Barraja P, Lauria A, Almerico AM, Cirrincione G, Minnei C, Longu S, Congiu D, Musiu C, La Colla P.
    Journal: Anticancer Res; 1999; 19(3A):2127-31. PubMed ID: 10470160.
    Abstract:
    A series of 2-triazenothiophene derivatives was prepared and tested to evaluate their biological activity. Two compounds inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. Compound 3c inhibited DNA, RNA and protein synthesis, and was also effective against KB cells resistant to etoposide and vincristine. The compounds were inactive against fungi and bacteria.
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