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  • Title: Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.
    Author: Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J.
    Journal: Mech Dev; 1999 Jun; 84(1-2):169-72. PubMed ID: 10473135.
    Abstract:
    The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression of Serrate1 (Jagged1), meanwhile becomes restricted to the supporting cells of each sensory patch. Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1.
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