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  • Title: [The demonstration of steady-state Ca2+ influx into the cells of the salivary glands in Chironomus plumosus L. larvae and its role in basal secretion].
    Author: Fedirko NV, Klevets' MIu.
    Journal: Fiziol Zh (1994); 1999; 45(4):84-91. PubMed ID: 10474807.
    Abstract:
    Ca2+ content in Chironomus plumosus salivary gland tissue we determined using Ca(2+)-sensitive dye arsenazo III and protein concentration in medium--by Lowry method. It was showed correlation between increasing of Ca2+ content in gland and basal secretion. So, basal secretion is Ca(2+)-dependent process. Owing to adding to medium verapamil, diltiazem and nifedipine (10(-4) M) took place decreasing of Ca2+ content and secretion. Since decreasing of Ca2+ entry in cells owing to blocators action did't exceed 53% (in the case of nifedipine) we assumed that permanent Ca2+ entry formed by potential- and receptor-operated channels. It was established dependence of continuous Ca2+ entry in cells, basal secretion and effectiveness of blockade of Ca(2+)-channels by nifedipine on the [Ca2+]e. Therefore, through the exocrine secretory cells membrane of Chironomus plumosus larvae salivary gland carry out continuous diffuse Ca2+ entry for maintain of basal secretion by cells. This Ca2+ entry provide by population of open Ca(2+)-channels, sensitive to blocators of potential dependent of Ca(2+)-conduction plasmatic membrane.
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