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  • Title: High prevalence of activated protein C resistance due to factor V leiden mutation in cases of intrauterine fetal death.
    Author: Rothbart H, Ohel G, Younis J, Lanir N, Brenner B.
    Journal: J Matern Fetal Med; 1999; 8(5):228-30. PubMed ID: 10475506.
    Abstract:
    OBJECTIVE: To test a possible association between activated protein C resistance and intrauterine fetal death. METHODS: The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy controls. RESULTS: Four women in the study group were heterozygotes for the factor V mutation and none of the controls. The mean activated protein C activity of the study group was statistically significantly lower than that of the controls (P = 0.013). CONCLUSION: Resistance to activated protein C activity may be of etiologic importance in some cases of intrauterine fetal death.
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