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  • Title: Encephalopathy associated with human herpesvirus 6 in a liver transplant recipient.
    Author: Paterson DL, Singh N, Gayowski T, Carrigan DR, Marino IR.
    Journal: Liver Transpl Surg; 1999 Sep; 5(5):454-5. PubMed ID: 10477848.
    Abstract:
    Recent reports have documented human herpesvirus 6 (HHV-6) as a cause of high fever, bone marrow depression, and rash in liver transplant recipients in the absence of another known pathogen. We describe a 49-year-old liver transplant recipient who developed confusion, occipital headache, and involuntary movements of the limbs 3 weeks after orthotopic liver transplantation. HHV-6 was detected in the peripheral blood using a rapid culture assay. Examination of cerebrospinal fluid by polymerase chain reaction for HHV-6 was also positive. No other pathogens were identified. The patient improved after commencement of intravenous ganciclovir therapy. This case suggests HHV-6 needs to be considered in the differential diagnosis of unexplained confusion in liver transplant recipients.
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