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  • Title: [Prediction of glycan structures of human N-glycoproteins].
    Author: Strecker G, Montreuil J.
    Journal: C R Acad Hebd Seances Acad Sci D; 1978 Oct 16; 287(9):887-90. PubMed ID: 104798.
    Abstract:
    By adding the sequence beta-(1 leads to 4)-GlcNAc-beta-(1 leads to)-Asn or alpha Fuc-(1 leads to 6 or 3)-beta-(1 leads to 4)-GlcNAc-beta-(1 leads to)-Asn to the oligosaccharides isolated from human urines of mannosidosis, fucosidosis and sialidosis, we are able to reconstitute numerous structures of asparaginyl-glycans. We postulate i) that these structures which have not yet been characterized pre-exist in glycans of human glycoproteins, probably in the cytoplasm or/and the cell membrane; ii) that they are products of the action of endo-beta-N-acetyl-glucosaminidases which are protected because of the lack of exoglycosidases and accumulate in the cells, and then in the urine.
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