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  • Title: [Aplastic anemia and viral hepatitis (posthepatitic aplastic anemia)].
    Author: Mikhaĭlova EA, Iadrikhinskaia VN, Savchenko VG.
    Journal: Ter Arkh; 1999; 71(7):64-9. PubMed ID: 10481870.
    Abstract:
    AIM: To validate up-to-date policy of immunosuppressive therapy of patients with aplastic anemia (AA) which has developed either at acute or chronic phase of viral hepatitis. MATERIALS AND METHODS: 16 patients with AA detected within 6 months (9 patients) or 12-36 months (7 patients) after acute viral hepatitis received immunosuppressive therapy (antilymphocytic globulin, cyclosporin A, splenectomy). RESULTS: Posthepatitis aplastic anemias ran a severe and treatment-resistant course in most cases. The immunosuppressive therapy produced a response in 44% of the patients. AA following acute viral hepatitis demands intensive and long-term immunosuppressive therapy with antilymphocytic globulin, cyclosporin A, splenectomy (in some cases) to achieve a persistent clinicohematological remission.
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