These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Indolo[3,2-c]cinnolines with antiproliferative, antifungal, and antibacterial activity.
    Author: Barraja P, Diana P, Lauria A, Passannanti A, Almerico AM, Minnei C, Longu S, Congiu D, Musiu C, La Colla P.
    Journal: Bioorg Med Chem; 1999 Aug; 7(8):1591-6. PubMed ID: 10482451.
    Abstract:
    A series of indolo[3,2-c]cinnoline derivatives was prepared and tested to evaluate their biological activity. Most of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. With the exception of 7g, all title compounds showed antibacterial activity against gram-positive bacteria, being up to 200 times more potent than the reference drug streptomycin. Some of the indolo[3,2-c]cinnolines were also endowed with good antifungal activity, particularly against Criptococcus neoformans.
    [Abstract] [Full Text] [Related] [New Search]