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  • Title: [The pharmacological correction of hemodynamics during the simulation of the early period of adaptation to weightlessness].
    Author: Shashko VS, Modin AIu, Il'ina SL, Sabaev VV, Shashkov AV, Potapov MG.
    Journal: Aviakosm Ekolog Med; 1999; 33(3):3-8. PubMed ID: 10485023.
    Abstract:
    Investigations of volunteered subjects in whom antiorthostatic hypokinesia was modeled by tilting the cranial end of the body by -15 degrees were to answer whether pharmacological countermeasures of the vestibular/autonomous syndrome (motion sickness, sea sickness) alter the orthostatic tolerance and cardiovascular parameters. As was stated, the drugs allow controlled correction of hemodynamic resistance to the head-down tilt. Ephedrine, phencarol, ephedrine combined with scopolamine and pipolphen, and stugeron normalized cerebral circulation. Medicaments were unable to moderate the sympathoadrenal reaction to the head-down tilt; however, blood concentrations of catecholamines were significantly lower than in the control. The greatest effect was achieved using ephedrine and ephedrine plus pipolphen.
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