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  • Title: [The expression of p16, CDK4 and pRb in hepatocellular carcinomas].
    Author: Luo D, Liu Q, Su J.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 1999 Jun; 7(2):94-5. PubMed ID: 10488417.
    Abstract:
    OBJECTIVE: To make an analysis of the expression of p16 gene, CDK4 and retinoblastoma protein(pRb) in human hepatocellular carcinoma(HCC). METHODS: Application of immunohistochemistry to 40 cases of HCC and their adjacent liver tissues. RESULTS: The abnormal expressions of p16, CDK4 and pRb were 94.44%(34/36), 40.00%(16/40) and 45.71%(16/35) respectively. Rb protein was strongly stained in 13/34(38.23%) cases lacking or weak staining with p16, which showed a negative relation between the expressions of Rb and p16. The abnormal expressions of both p16 and Rb were 15/34(44.11%) cases, indicating that except p16, there are some other ways to regulate Rb. In 14 cases of CDK4 overexpression, most of them (92.85%) presented p16 aberration, 50.00% of them were observed with pRb abnormal expression, 46.15% of them were along with the alterations of both p16 and pRb. There was no significant correlation between p16 or CDK4 or pRb abnormal expression and HCC malignant grade. CONCLUSION: The data show that the aberrant expression of p16, CDK4 and pRb may play a role in the carcinogenesis of HCC. The changes of p16 expression is prominent.
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