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  • Title: [Polypeptides from influenza virus, obtained in the presence of high concentrations of rimantadine].
    Author: Boreko EI, Pavlova NI, Votiakov VI.
    Journal: Vopr Virusol; 1998; 43(6):270-4. PubMed ID: 10488531.
    Abstract:
    FPV/Rostock obtained in the presence of remantadine (25 micrograms/ml) is studied. This variant of the virus is characterized by a decreased amount of M1-protein. Its buoyant density in urograffin density gradient is 1.20 gamma/cm3 vs. 1.18 and 1.175 g/cm3 for initial FPV and remantadine-resistant FPV, respectively. Purification and concentration decreases the hemagglutinating activity of the virus 5-10 times more intensely than that of initial and remantadine-resistant FPV. On the other hand, the production of virus-specific proteins and intracellular distribution of hemagglutinin in this virus variant were not changed. The changes associated with a decrease of hemagglutinin and M1-protein content in virions are believed to manifest at a later stage preceding virion release from the cell.
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