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  • Title: Coincident induction of long-term facilitation in Aplysia: cooperativity between cell bodies and remote synapses.
    Author: Sherff CM, Carew TJ.
    Journal: Science; 1999 Sep 17; 285(5435):1911-4. PubMed ID: 10489370.
    Abstract:
    Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Evidence is presented here that if Aplysia sensory neuron somata and their remote motor neuron synapses are simultaneously exposed to serotonin pulses insufficient to induce long-term facilitation (LTF) at either site alone, processes activated at these sites interact to induce LTF. This coincident induction of LTF requires that (i) the synaptic pulse occur within a brief temporal window of the somatic pulse, and (ii) local protein synthesis occur immediately at the synapse, followed by delayed protein synthesis at the soma.
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