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  • Title: [The effect of central serotonin administration on the neurogenic damage to the gastric mucosa due to chronic social stress in inbred mice].
    Author: Koriakina LA.
    Journal: Ross Fiziol Zh Im I M Sechenova; 1999 Mar; 85(3):454-61. PubMed ID: 10494598.
    Abstract:
    A reiterated negative experience of intermale confrontations for 3 and 10 days resulted in aggravation of neurogenic ulceration of gastric mucosa in defeated males from all strains of mice under study, the number of mucosa erosions being 2-3-fold greater than in winners or control animals. Administration of serotonine into the lateral ventricles increased the number of erosions in intact mice of all genotypes. In experimental groups, a considerable diversity was found in respect to the effects of exogenous serotonine on the gastric mucosa. Following 10 days of the stress, both in winners and losers, a decrease of the gastric mucosa sensitivity to central serotonine was revealed.
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