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  • Title: Influvac: a safe Madin Darby Canine Kidney (MDCK) cell culture-based influenza vaccine.
    Author: Brands R, Visser J, Medema J, Palache AM, van Scharrenburg GJ.
    Journal: Dev Biol Stand; 1999; 98():93-100; discussion 111. PubMed ID: 10494962.
    Abstract:
    Influenza vaccine production technology based on large scale cell culture technology has been developed. From the characterization of the continuous cell line MDCK as well as drug safety studies we conclude that this cell line and the cell culture system are suitable for biological production. The Down Stream Process (DSP) of the virus-containing harvest fluids guarantees sufficient inactivation of influenza viruses and adequate removal or inactivation of putative adventitious or endogenous viruses, mycoplasma or bacteria. Our data indicate that the tissue culture-based production technology is feasible.
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