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  • Title: [Variability of the structure of neurotoxins from the scorpion Orthochirus scrobiculosus from various natural habitats].
    Author: Lipkin AV, Grishin EV.
    Journal: Bioorg Khim; 1999 May; 25(5):341-7. PubMed ID: 10495891.
    Abstract:
    To study the structural variability of the Os3 neurotoxin from the venom of scorpion Orthochirus scrobiculosus inhabiting Uzbekistan and Turkmenia, a cloning method for the family of cDNAs that encode the highly homologous Os3-like polypeptides was developed. The Turkmenian scorpion venom was shown to contain a family of closely related Os3-like polypeptides. Mass-spectrometry indicated that crude venoms from scorpions in-habiting these two regions of Central Asia differ in the amino acid composition of their toxic components depending on the habitat.
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