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  • Title: [Dependence of synergism of the combined effect of cisplatin and hyperthermia on the concentration of the drug].
    Author: Pantiukhina AG, Petin VG.
    Journal: Tsitologiia; 1999; 41(5):420-4. PubMed ID: 10496016.
    Abstract:
    The analysis of synergistic interaction of cisplatin of various concentrations and high temperature on Chinese hamster fibroblasts was performed using a mathematical model. To calculate the synergistic interaction some survival curves obtained after separate and simultaneous combined actions of these agents reported elsewhere have been used. A good agreement between experimental data and the mathematical model prognosis was provided. For a constant temperature, synergism was observed only within a certain range of cisplatin concentration. The highest value of synergism was shifted towards a lower concentration with a decrease in the temperature, at which the combined treatment was carried out. Possible practical utilization of this rule in radiation therapy, medical and food sterilization, and ecology are discussed.
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