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  • Title: Rapid mass screening method and counseling for the 1555A-->G mitochondrial mutation.
    Author: Usami S, Abe S, Shinkawa H, Inoue Y, Yamaguchi T.
    Journal: J Hum Genet; 1999; 44(5):304-7. PubMed ID: 10496072.
    Abstract:
    The 1555A-->G point mutation is associated with a susceptibility to aminoglycoside antibiotics, and is of particular interest, as it may cause hearing loss even without aminoglycoside exposure. There may be a considerably large high-risk population in Japan, and to avoid possible side effects in this group, a rapid mass screening system and careful counseling are recommended. We are currently using the mutant allele specific amplification (MASA) method to detect the 1555A-->G mitochondrial mutation and we distribute a warning card to subjects found to bear this mutation.
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