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  • Title: Methemoglobinemia secondary to topical silver nitrate therapy--a case report.
    Author: Chou TD, Gibran NS, Urdahl K, Lin EY, Heimbach DM, Engrav LH.
    Journal: Burns; 1999 Sep; 25(6):549-52. PubMed ID: 10498367.
    Abstract:
    Methemoglobinemia is a rare complication in individuals exposed to nitrates or nitrites. Whereas methemoglobinemia is a recognized potential complication in burn patients treated with topical 0.5% silver nitrate solution, no report of methemoglobinemia in burn patients has been present in the literature for more than 15 years. We raise consciousness about this complication with a case report of a 12-month-old child with necrotizing fasciitis resulting from a cutaneous flank infection. The patient developed cyanosis 20 days after initiation of topical treatment with 0.5% silver nitrate solution. Intravenous injection of methylene blue can restore normal blood oxygenation.
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