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  • Title: Evaluating chiral separation interactions by use of diastereomeric polymeric dipeptide surfactants.
    Author: Billiot E, Thibodeaux S, Shamsi S, Warner IM.
    Journal: Anal Chem; 1999 Sep 15; 71(18):4044-9. PubMed ID: 10500490.
    Abstract:
    Poly sodium N-undecyl leucine-leucine (poly SULL) is used as a diagnostic tool to investigate chiral molecular interactions via electrokinetic chromatography (EKC). Poly SULL has two chiral centers which are defined by two asymmetric carbons. Each chiral center of poly SULL can have two possible configurations (D or L). Consequently, four different optical configurations are possible within the surfactant molecule (L-L, D-D, L-D, and D-L). In this study, five chiral analytes of various charge states and hydrophobicities were used to investigate the role of electrostatic interactions and hydrophobicity on chiral recognition with polymeric dipeptide surfactants. These studies lead to a proposed hypothesis for interaction of the analytes with dipeptide surfactants. The hypothesis was tested and the contribution of the double chiral centers to this interaction was evaluated by use of two dipeptide surfactants in which one chiral amino acid is replaced by an achiral amino acid glycine, i.e., poly sodium N-undecyl L-leucine-glycine (poly L-SULG) and poly sodium N-undecyl L-glycine-leucine (poly L-SUGL). The results reported here provide new insights into the mechanism for chiral recognition of select chiral analytes by use of polymeric chiral surfactants.
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