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  • Title: Early steps of replication of moloney murine leukemia virus in resting lymphocytes.
    Author: Piéroni L, Bouillé P, Auclair C, Guillosson JJ, Nafziger J.
    Journal: Virology; 1999 Sep 30; 262(2):408-15. PubMed ID: 10502519.
    Abstract:
    We explored the role of cell type in the early steps of replication of Moloney murine leukemia virus (Mo-MLV) by comparing viral entry and reverse transcription in physiologically quiescent peripheral blood B and T lymphocytes. Virus entry was identical in both cell types. In contrast to previous results, full-length viral DNA was synthesized in resting B lymphocytes, but in agreement with earlier reports, reverse transcription was abortive in resting T lymphocytes. The addition of exogenous nucleosides in the culture medium of resting T lymphocytes allowed reverse transcription to proceed in these cells, without inducing cell cycling. These data suggest that the difference in the ability of quiescent T and B lymphocytes to sustain reverse transcription of Mo-MLV can be explained by a difference in the dNTP pool sizes of these two populations of quiescent cells.
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