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  • Title: Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia.
    Author: Bell RL, Vaccarino AL, Olson RD, Olson GA, Nores WL, Cambre JG, Zadina JE, Kastin AJ.
    Journal: Peptides; 1999; 20(8):971-8. PubMed ID: 10503776.
    Abstract:
    Tolerance and cross-tolerance between Tyr-W-MIF-1, a mixed micro-agonist/antagonist, and morphine were examined. Opiate dependence also was examined. Rats were pretreated with Tyr-W-MIF-1, morphine, or saline for 4 days. On day 5, the animals were tested for Tyr-W-MIF-1 analgesia, morphine analgesia, or naloxone-precipitated withdrawal. Tyr-W-MIF-1- and morphine-pretreated animals showed similar levels of dependence. Animals pretreated with Tyr-W-MIF-1 failed to express tolerance to Tyr-W-MIF-1 analgesia but did display cross-tolerance to morphine analgesia. Animals pretreated with morphine displayed tolerance to morphine analgesia but did not express cross-tolerance to Tyr-W-MIF-1 analgesia. Therefore, tolerance and morphine-induced cross-tolerance were not expressed to Tyr-W-MIF-1 analgesia.
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