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  • Title: Ochronosis: an unusual finding at aortic valve replacement.
    Author: Helou J, Masters RG, Keon WJ, Veinot JP.
    Journal: Can J Cardiol; 1999 Sep; 15(9):1013-5. PubMed ID: 10504183.
    Abstract:
    The condition known as ochronosis refers to the accumulation of oxidized homogentisic acid in the connective tissues of alkaptonuric patients. The diagnosis is usually made from the triad of degenerative arthritis, ochronotic connective tissue pigmentation and urine that turns dark brown or black on alkalinization. Cardiovascular disease is a less well appreciated aspect of this disorder. A patient with ochronosis of his stenotic aortic valve is reported. The role of the pigment in the genesis of the valve degeneration is discussed.
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