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  • Title: Direct projections from the medial preoptic area to spinally-projecting neurons in Barrington's nucleus: an electron microscope study in the rat.
    Author: Ding YQ, Wang D, Xu JQ, Ju G.
    Journal: Neurosci Lett; 1999 Aug 27; 271(3):175-8. PubMed ID: 10507697.
    Abstract:
    Direct projections from the medial preoptic area (MPO) to the pontine micturition center neurons directly projecting to the lumbosacral spinal cord were revealed electron microscopically in the rat by a double labeling method. Biotinylated dextran amine (BDA) was injected into the MPO and horseradish peroxidase (HRP) was injected into the lumbosacral cord segments. At light microscopic level, BDA-labeled presumptive axon terminals completely overlapped with HRP-labeled neurons in Barrington's nucleus. Electron microscopic observation showed that some BDA-labeled axon terminals made synaptic contacts with dendrites of HRP-labeled neurons in Barrington's nucleus. The present results indicated that the MPO may be involved in the modulation of the pontine micturition reflex in the rat.
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