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  • Title: Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases.
    Author: Kaibuchi K, Kuroda S, Fukata M, Nakagawa M.
    Journal: Curr Opin Cell Biol; 1999 Oct; 11(5):591-6. PubMed ID: 10508646.
    Abstract:
    Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion. IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and beta-catenin and induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.
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