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  • Title: Recent advances in xenotransplantation.
    Author: Sandrin MS, McKenzie IF.
    Journal: Curr Opin Immunol; 1999 Oct; 11(5):527-31. PubMed ID: 10508710.
    Abstract:
    The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galalpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galalpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.
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