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  • Title: Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles.
    Author: Pae AN, Kim HY, Joo HJ, Kim BH, Cho YS, Choi KI, Choi JH, Koh HY.
    Journal: Bioorg Med Chem Lett; 1999 Sep 20; 9(18):2679-84. PubMed ID: 10509915.
    Abstract:
    Two series of oxazolidinone derivatives having substituted isoxazoles were synthesized and tested for antibacterial activities against several Gram-positive strains including the resistant strains of Staphylococcus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed in vitro activities (MIC) comparable or superior to the reference compound vancomycin.
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