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  • Title: Drugs of abuse and brain gene expression.
    Author: Torres G, Horowitz JM.
    Journal: Psychosom Med; 1999; 61(5):630-50. PubMed ID: 10511013.
    Abstract:
    Addictive drugs like cocaine, ethanol, and morphine activate signal transduction pathways that regulate brain gene expression. Such regulation is modulated by the presence of certain transcription factor proteins present in a given neuron. This article summarizes the effects of several addictive drugs on transcriptional processes contributing to the development of a drug-dependent state. The characterization of drug-induced changes in gene expression shows promise for improving our understanding of drug-addiction phenomena and cellular modes of cocaine, ethanol, and morphine action.
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