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  • Title: Teicoplanin pharmacokinetics in critically ill paediatric patients.
    Author: Sánchez A, López-Herce J, Cueto E, Carrillo A, Moral R.
    Journal: J Antimicrob Chemother; 1999 Sep; 44(3):407-9. PubMed ID: 10511412.
    Abstract:
    Twenty-one critically ill children aged between 7 days and 12 years were treated with teicoplanin (three loading dosages of 10 mg/kg at 12 h intervals, followed by a maintenance dosage of 10 mg/kg/day). Serum teicoplanin concentrations were monitored by HPLC. Mean concentrations in plasma 30 min after drug administration were 20 +/- 16.1 mg/L. The volume of distribution was 0.30 L/kg and the terminal half-life was 17.41 h. Only 11% of trough values were >10 mg/L (established as desirable values). In critically ill children a dosage of 10 mg/kg/day does not assure serum trough values >10 mg/L.
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