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  • Title: [Anesthetic management of a patient with Coffin-Lowry syndrome].
    Author: Hashiguchi K, O'Higashi T, Sasai S, Kiguchi T, Uga H, Matsuura H.
    Journal: Masui; 1999 Sep; 48(9):1027-9. PubMed ID: 10513184.
    Abstract:
    Coffin-Lowry syndrome (CLS) is characterized by mental retardation, a peculiar face and deformities of the thorax and spine. A 33-year-old female with Coffin-Lowry syndrome (CLS), further complicated with atrial septal defect and ventricular tachycardia, underwent elective surgery for anterior cervical cyst. As difficult intubation had been anticipated, anesthesia was induced with continuous administration of propofol. After confirming that she could be ventilated by mask, vecuronium bromide, midazolam and fentanyl were given. The operation and anesthesia were conducted uneventfully. No complications occurred postoperatively. The use of propofol for slow induction of anesthesia was advantageous for hemodynamic stability in this case.
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