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  • Title: Intoxication due to negative canrenone interference in digoxin drug monitoring.
    Author: Steimer W, Müller C, Eber B, Emmanuilidis K.
    Journal: Lancet; 1999 Oct 02; 354(9185):1176-7. PubMed ID: 10513714.
    Abstract:
    Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.
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